gc-os-ai

gc-os-ai/pyaptamer

The python library for easy aptamer design.

47 stars 131 forks 47 watchers Python BSD 3-Clause "New" or "Revised" License

15 Open Issues Need Help Last updated: Jul 6, 2026

Open Issues Need Help

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[ENH] `deepDNAshape` reworked 2 days ago

enhancement good first issue

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

Investigate (and implement) how prot words are obtained for AptaTrans about 2 months ago

good first issue easy

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[BUG] GreedyEncoder.get_test_params should be a `classmethod` (skbase contract) 2 months ago

bug good first issue easy

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

Clean implementation of AptaMCTS 2 months ago

enhancement good first issue

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[ENH] move `pairs_to_features`, `generate_kmer_vecs` and other similar utilities to transformer interface 3 months ago

enhancement good first issue medium

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[BUG] AptaNetPipeline rejects AptaCom-style training DataFrames 3 months ago

enhancement good first issue

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

PSeAAC on in-memory `MoleculeLoader` 3 months ago

enhancement good first issue

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[BUG] Finetuning crashes with AMP: `binary_cross_entropy` is unsafe to autocast (needs BCEWithLogitsLoss or disable autocast for loss) 3 months ago

bug good first issue easy

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[ENH] python bindings to load Aptacom data set 3 months ago

good first issue medium

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[ENH] aptacom algorithm 3 months ago

enhancement good first issue hard

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[ENH] AptaTrans test coverage 3 months ago

enhancement good first issue medium

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[ENH] Replacing `seq_id` with `chain_id` 4 months ago

enhancement good first issue easy

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

Hugging Face AptaCom dataset test fails occasionally 4 months ago

bug good first issue

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[API] revisiting in-memory representation of `pdb`/ `mmcif` 9 months ago

help wanted

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python

[ENH] Reorganize experiments in separate modules 9 months ago

enhancement good first issue

gc-os-ai/pyaptamer

47

The python library for easy aptamer design.

Python